Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism
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چکیده
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The transcription factor NF-E2-related factor 2 (Nrf2) induces cytoprotective genes, but has also been linked to the regulation of hepatic energy metabolism. In order to assess the pharmacological potential of hepatic Nrf2 activation in metabolic disease, Nrf2 was activated over 7 weeks in mice on Western diet using two different siRNAs against kelch-like ECH-associated protein 1 (Keap1), the i...
متن کاملCorrection: Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice
[This corrects the article DOI: 10.1371/journal.pone.0166110.].
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2021
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2021.101243